AP-001 (neuroprotectin D1; NPD1/ protectin D1; PD1)

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Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature
2014;510:92-101

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Schwab JM, Chiang N, Arita M, and Serhan CN. Resolvin E1 and protectin D1 activate
inflammation-resolution programmes. Nature Letters 2007;447:869-75

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Connor KM, SanGiovanni JP, Lofquist C, et al. Increased dietary intake of omega-3-
polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nature Med 200713:868-
73

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Sheets KG, Zhou Y, Ertel MK, et al. Neuroprotectin D1 Attenuates Laser-induced Choroidal
Neovascularization in Mouse. Molecular Vision 2010;16:320-329

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Sheets KG, Bokkyoo J, Zhou Y et al. Microglial ramification and redistribution concomitant with
the attenuation of choroidal neovascularization by neuroprotectin D1. Molecular Vision
2013;19:1747-59

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Rajasagi N, Reddy PBJ, Mulik S et al. Neuroprotectin D1 reduces the severity of herpes simplex
virus-induced corneal immunopathology. Invest Ophthalmol Vis Sci 2013;54:6269-79

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Cortina MS, He J, Russ T et al. Neuroprotectin D1 restores corneal nerve integrity and function
after damage from experimental surgery. Invest Ophthalmol Vis Sci 2013;54:4109-16

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Gjorstrup P, Mukherjea D, Dhukhwa A, et al. AP-001/NPD1 pleiotropic actions on multiple
targets confer protection from cisplatin-induced hearing loss. Inner Ear Biology 55 th International
Workshop, Berlin 2018, EIB 2018, Abstract OP-04;006

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Antony R, Lukiw WJ, and Bazan NG. Neuroprotectin D1 Induces Dephosphorylation of Bcl-xL in
a PP2A-dependent Manner during Oxidative Stress and Promotes Retinal Pigment Epithelial
Cell Survival. J Biol Chem 2010;285:18301-18308

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Calandria JM, Mukherjee PK, Rivero Vaccari de JC et al. Ataxin-1poly(Q)-induced proteotoxic
stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived
neuroprotectin D1. J Biol Chem 2012;287:23726-39

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Musto AE, Walker CP, Petasis NA, and Bazan NG. Hippocampal neuro-networks and dendritic
spine perturbations in epileptogenesis are attenuated by neuroprotectin D1. PLoS ONE
2015;10(1):e0116543

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Park CK, Lü N, Xu ZZ, et al. Resolving TRPV1 and TNF-a-mediated spinal cord synaptic
plasticity and inflammation pain with neuroprotectin D1. J Neurosci 2011;31:15072-85

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Asatryan A and Bazan NG. Molecular mechanisms of signaling via the docosanoid
neuroprotectin D1 for cellular homeostasis and neuroprotection. JBC Minireview. J Biol
Chem 2017;292:12390-7

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CLINICAL INDICATIONS

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Blencowe H, Lawn JE, Vazquez T et al. Preterm-associated visual impairment and estimates of
retinopathy of prematurity at regional and global levels for 2010. Ped Res 2013; 74:35-49

Hellström A, Smith LE, and Dammann O. Retinopathy of prematurity. Lancet. 2013;26:1445-57

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Ardeljan D and Chan C-C. Aging is not a disease: distinguishing age-related macular
degeneration from aging. Prog Retin Eye Res 2013;37:68-89

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Wong WL, Su X, Li X, el. Global prevalence of age-related macular degeneration and disease
burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob
Health 2014; 2:e:106-16

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Clemens E, de Vries AC, Pluijm SF, et al. Determinants of ototoxicity in 451 platinum-treated
Dutch survivors of childhood cancer: a DCOG late-effects study. Eur J of Cancer 2016;69:77-85

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Landier W, Knight K, Wong FL et al. Ototoxicity in children with high-risk neuroblastoma:
prevalence, risk factors, and concordance of grading scales – a report from the Children’s
Oncology Group. J Clin Oncol 2014;32:527-34

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Ferriero DM. Neonatal brain injury. New Eng J Med 2004;351:1958-95

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Hagberg H, Edwards AD and Groenendaal F. Perinatal brain damage: The term infant.
Neurobiology of Disease 2016;92:102-12

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